Potassium Hydroxide → 2-Amino-4-methyl-6-(4-phenylbutyl)pyridine

HRID 1740981

反応式

HRID 1740981 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:5]=[C:4]([N:18]2C(C)=CC=C2C)[CH:3]=1.Cl.NO.[OH-].[K+]>C(O)C.O>[NH2:18][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:5]=1

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 218344204-Methyl-2-(2,5-dimethylpyrrol-1-yl)-6-(4-phenylbutyl)pyridine

生成物 1

HCID 98561822-Amino-4-methyl-6-(4-phenylbutyl)pyridine

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

By analogy to Example 56, Step B, 4-methyl-2-(2,5-dimethylpyrrol-1-yl)-6-(4-phenylbutyl)pyridine was treated with 4,6 equivalents of hydroxylamine hydrochloride and 2.8 equivalents of potassium hydroxide in refluxing ethanol/water to yield 2-amino-4-methyl-6-(4-phenylbutyl)pyridine as a yellow oil.

出典と根拠

ORDレコード
ord-a45e950eea1f47caaf71ec61abbd3d97
出典データセット
uspto-grants-1999_10
特許番号
US05972975

関連ノート

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