Hydrochloric Acid → 1-Acetyl-7-hydroxy-2,3,4,5-tetrahydro-1H-benzazepine
反応式
C([O:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]([C:15](=[O:17])[CH3:16])[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:18]=1)(=O)C.[OH-].[Na+].Cl>C(O)C.O>[C:15]([N:14]1[C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[CH:18][C:9]=2[CH2:10][CH2:11][CH2:12][CH2:13]1)(=[O:17])[CH3:16]参加物
6
実験手順
7-Acetoxy-1-acetyl-2,3,4,5-tetrahydro-1H-benzazepine (D23, 3.88 g, 16 mmol) was stirred in ethanol (40 ml) as NaOH (1.26 g, 32 mmol) was added in water (5 ml). After stirring for 30 min, the mixture was diluted with water (500 ml), and acidified with 5M HCl. The tan precipitate was filtered off and dried, yielding 2.02 g (63%) of the title compound. A further 0.80 g (25%) of this material was isolated by dichloromethane extraction of the filtrate.
後処理
- filtrationThe tan precipitate was filtered off
- customdried
出典と根拠
- ORDレコード
- ord-b8ad193304a448c9b19819e47a0f6ce6
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05972951
反応ノート
読み込み中…