Sodium Azide → 3-(3,4-Dimethylphenoxy)propan-1-amine
反応式
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([CH3:13])[CH:7]=1.[N-:14]=[N+]=[N-].[Na+]>C1(C)C=CC=CC=1.[N+](CCCC)(CCCC)(CCCC)CCCC.[Br-]>[CH3:13][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][C:9]=1[CH3:12])[O:5][CH2:4][CH2:3][CH2:2][NH2:14]参加物
5
実験手順
9.05 (45.6 mnol) of 1-chloro-3-(3,4-dimethylphenoxy)- propane obtained in step 1 was dissolved in 200 ml of toluene. To the resulting solution were added 14.8 g of NaN3, 2.9 g of n-Bu4NBr and 15.2 g of KI and the mixture was refluxed For 24 hours. The reaction mixture was washed with water and concentrated under a reduced pressure. The resulting residue was purified by chromatography (ethyl acetate: hexane=1:10) to obtain 9.04 g (yield 97%) of the title compound as a brown oil.
後処理
- temperaturethe mixture was refluxed For 24 hours
- washThe reaction mixture was washed with water
- concentrationconcentrated under a reduced pressure
- customThe resulting residue was purified by chromatography (ethyl acetate: hexane=1:10)
出典と根拠
- ORDレコード
- ord-42222539caee4c66b6c68e2f9089150a
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05973201
反応ノート
読み込み中…