3-(3,4-Dimethylphenoxy)propylazide → 3-(3,4-Dimethylphenoxy)propan-1-amine
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[CH3:15])[O:5][CH2:6][CH2:7][CH2:8][N:9]=[N+]=[N-].[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[CH3:15])[O:5][CH2:6][CH2:7][CH2:8][NH2:9]参加物
5
実験手順
6.20 g (30.2 mmol) of 3-(3,4-dimethylphenoxy)propylazide obtained in step 2 was dissolved in 150 ml of ethyl acetate and then 4.99 g of 5% Pd/C was added thereto to carry out a hydrogenation reaction at a hydrogen pressure of 40 psi for 30 minutes. The reaction mixture was passed through a Celite™ layer to remove Pd/C, concentrated under a reduced pressure to produce a residue, which was distilled under a reduced pressure to obtain 2.59 g (yield 48%) of the title compound as a colorless oil.
後処理
- customto remove Pd/C
- concentrationconcentrated under a reduced pressure
- customto produce a residue, which
- distillationwas distilled under a reduced pressure
出典と根拠
- ORDレコード
- ord-b660e26f51f140408653144cb589466b
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05973201
反応ノート
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