HCID 21834627、化合物 → N-Methyl-gamma-phenylbenzenepropanamine

HRID 1741474ノート

反応式

HRID 1741474 の反応式
[CH2:1]([N:8]([CH2:10][CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C)C1C=CC=CC=1>CO.Cl.[OH-].[Pd+2].[OH-]>[CH3:1][NH:8][CH2:10][CH2:11][CH:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

5

反応物 1

HCID 21834627HCID 21834627、化合物

生成物 1

HCID 119812N-Methyl-gamma-phenylbenzenepropanamine

試薬・触媒・溶媒 3

HCID 9942167Palladium hydroxide触媒HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

A solution of N-benzyl-N-methyl-3,3-diphenylpropylamine (1.03 g, 3.27 mmol) in methanol (35 ml) and aq. HCl (0.27 ml, of a 12.1M aq. solution, 3.3 mmol) was purged with argon and palladium hydroxide (405 mg) added. The flask was evacuated and shaken under an atmosphere of hydrogen (50 psi) for 18 hrs. The hydrogen was replaced by argon and the catalyst removed by filtration. The filtrate was treated with aq. NaOH (100 ml of a 1 M solution) and extracted into Et2O. The organic extracts were dried (Na2SO4) and evaporated in vacuo to afford the title compound as an oil.

後処理

  1. additionadded
  2. customThe flask was evacuated
  3. customthe catalyst removed by filtration
  4. additionThe filtrate was treated with aq. NaOH (100 ml of a 1 M solution) and
  5. extractionextracted into Et2O
  6. dry with materialThe organic extracts were dried (Na2SO4)
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-56f98a93da624136bb962b957c13c93d
出典データセット
uspto-grants-1999_10
特許番号
US05972984

反応ノート

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