Tetrabutylammonium Fluoride → 4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2,6-dipropyl-phenol
反応式
[Si]([O:8][C:9]1[C:14]([CH2:15][CH2:16][CH3:17])=[CH:13][C:12]([CH2:18][N:19]2[C:23]3=[N:24][C:25]([CH3:29])=[CH:26][C:27]([CH3:28])=[C:22]3[N:21]=[C:20]2[CH2:30][CH3:31])=[CH:11][C:10]=1[CH2:32][CH2:33][CH3:34])(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[CH3:29][C:25]1[N:24]=[C:23]2[N:19]([CH2:18][C:12]3[CH:11]=[C:10]([CH2:32][CH2:33][CH3:34])[C:9]([OH:8])=[C:14]([CH2:15][CH2:16][CH3:17])[CH:13]=3)[C:20]([CH2:30][CH3:31])=[N:21][C:22]2=[C:27]([CH3:28])[CH:26]=1参加物
4
実験手順
A THF solution of 5.0 g (10.44 mmol) of the product of Step F was treated with tetrabutylammonium fluoride (1.2 equiv, 1M solution in THF) overnight. THF was removed in vacuo and the residue was flash chromatographed using 30-50% ethyl acetate in hexane as eluent to afford 3.35 g (88%) of the title compound.