HCID 19010813、化合物 → HCID 19010736、化合物

HRID 1741838ノート

反応式

HRID 1741838 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH:9]=[C:10]([CH3:12])[CH3:11])[CH:6]=[CH:5][C:4]=1[C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17]>[Pd]>[CH2:9]([C:7]1[CH:6]=[CH:5][C:4]([CH:13]([OH:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:3]([O:2][CH3:1])[CH:8]=1)[CH:10]([CH3:12])[CH3:11]

参加物

3

反応物 1

HCID 19010813HCID 19010813、化合物

生成物 1

HCID 19010736HCID 19010736、化合物収率 98.4%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A mixture of 2'-methoxy-4'-(2-methyl-1-propenyl)valerophenone (88 mg) and 10% palladium on carbon (30 mg) was stirred under hydrogen atmosphere for 30 minutes. Catalyst was removed by filtration and the filtrate was concentrated. The residue was dissolved in methanol (5 ml) and then sodium borohydride (16 mg) was added. The reaction mixture was stirred at room temperature for 30 minutes. The mixture was poured into ice water and acidified with 6N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate and concentrated to give 1-(4-isobutyl-2-methoxyphenyl)pentanol (88 mg) as an oil.

後処理

  1. customCatalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. dissolutionThe residue was dissolved in methanol (5 ml)
  4. additionsodium borohydride (16 mg) was added
  5. stirringThe reaction mixture was stirred at room temperature for 30 minutes
  6. additionThe mixture was poured into ice water
  7. extractionextracted with ethyl acetate
  8. washThe organic layer was washed with water and brine
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated

出典と根拠

ORDレコード
ord-4fe0070c9d9b4f1dbe277653f92ae6c5
出典データセット
uspto-grants-1994_08
特許番号
US05334716

反応ノート

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