Sodium Hydroxide → HCID 11734695、化合物

HRID 1741849ノート

反応式

HRID 1741849 の反応式
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([NH:22][C:23]2[CH:24]=[C:25]([CH:45]=[CH:46][CH:47]=2)[C:26]([C:28]2[CH:29]=[C:30]([CH2:37][CH2:38][CH2:39][C:40]([O:42]CC)=[O:41])[N:31]3[C:36]=2[CH:35]=[CH:34][CH:33]=[CH:32]3)=[O:27])[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Na+]>C(O)C>[CH2:18]([C:15]1[CH:14]=[CH:13][C:12]([CH:11]([NH:22][C:23]2[CH:24]=[C:25]([CH:45]=[CH:46][CH:47]=2)[C:26]([C:28]2[CH:29]=[C:30]([CH2:37][CH2:38][CH2:39][C:40]([OH:42])=[O:41])[N:31]3[C:36]=2[CH:35]=[CH:34][CH:33]=[CH:32]3)=[O:27])[C:8]2[CH:7]=[CH:6][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:10][CH:9]=2)=[CH:17][CH:16]=1)[CH:19]([CH3:20])[CH3:21]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 11072251Ethyl 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyrate

生成物 1

HCID 11734695HCID 11734695、化合物収率 85.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]-butyrate (279 mg) in ethanol (10 ml) was added 4N sodium hydroxide (0.44 ml). Stirring was continued for 1 hour at 40° C. The reaction mixture was evaporated in vacuo, then added a solution of potassium dihydrogen phosphate (300 mg) in water and 1N hydrochloric acid (26 ml), and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate. After evaporation of the solvent, the residue was chromatographed on silica gel eluting with ethyl acetate to give 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid (229 mg).

後処理

  1. customThe reaction mixture was evaporated in vacuo
  2. additionadded a solution of potassium dihydrogen phosphate (300 mg) in water and 1N hydrochloric acid (26 ml)
  3. extractionextracted with ethyl acetate
  4. dry with materialThe combined organic layers were dried over sodium sulfate
  5. customAfter evaporation of the solvent
  6. customthe residue was chromatographed on silica gel eluting with ethyl acetate

出典と根拠

ORDレコード
ord-7f0f3c348cd740c1a6e3db3c78351091
出典データセット
uspto-grants-1994_08
特許番号
US05334716

反応ノート

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