Hydrochloric Acid → 7-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-2,4-dimethyl-2-chloroacetyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine

HRID 1742195ノート

反応式

HRID 1742195 の反応式
FC(F)(F)C(O)=O.[ClH:8].[Cl:9][C:10]1[CH:33]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:31]=[C:30]([F:38])[C:11]=1[O:12][C:13]1[CH:29]=[CH:28][C:16]2[N:17]([CH3:27])[C:18](=[O:26])[C:19]([C:22](=[O:25])[CH2:23]O)([CH3:21])[O:20][C:15]=2[CH:14]=1>ClCCl>[Cl:9][C:10]1[CH:33]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:31]=[C:30]([F:38])[C:11]=1[O:12][C:13]1[CH:29]=[CH:28][C:16]2[N:17]([CH3:27])[C:18](=[O:26])[C:19]([C:22](=[O:25])[CH2:23][Cl:8])([CH3:21])[O:20][C:15]=2[CH:14]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 190085937-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-2,4-dimethyl-2-hydroxyacetyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine2 回

生成物 1

HCID 190085957-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-2,4-dimethyl-2-chloroacetyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In Example 15, dichloromethane was used as the solvent, and trifluoroacetic acid or conc. hydrochloric acid was used in place of hydroiodic acid, and 7-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-2,4-dimethyl-2-hydroxyacetyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine (Compound 95) and 7-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-2,4-dimethyl-2-chloroacetyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine (Compound 97) were obtained.

出典と根拠

ORDレコード
ord-f8ba8dbcee8f45b38b4977a5acfbc621
出典データセット
uspto-grants-1994_08
特許番号
US05338719

反応ノート

読み込み中…