Sodium Carbonate → 4-(2-Bromoethyl)-1,2-dimethylbenzene

HRID 1742711ノート

反応式

HRID 1742711 の反応式
P(Br)(Br)[Br:2].[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[CH2:9][CH2:10]O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)(Cl)Cl.O>[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[CH2:9][CH2:10][Br:2]

参加物

6

反応物 3

HCID 10340Sodium CarbonateHCID 24614Phosphorus tribromideHCID 339432-(3,4-Dimethylphenyl)ethanol

生成物 1

HCID 225073204-(2-Bromoethyl)-1,2-dimethylbenzene

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 5943Carbon Tetrachloride溶媒

実験手順

Phosphorus tribromide (0.82 g) was added dropwise to a solution of 3,4-dimethylphenethyl alcohol (1.27 g--see Preparation 17) in carbon tetrachloride (10 ml). The mixture was heated under reflux for 2.5 hours then cooled to room temperature and basified (pit 8) by the dropwise addition of 10% aqueous sodium carbonate (5 ml). The mixture was then diluted with water (20 ml) and extracted with dichloromethane (3×50 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give the title compound as a colourless oil, yield, 0.5g.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 2.5 hours
  3. extractionextracted with dichloromethane (3×50 ml)
  4. dry with materialThe combined dichloromethane extracts were dried (MgSO4)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-908ce39a84834261a6c3f1b81c199a4a
出典データセット
uspto-grants-1994_08
特許番号
US05340831

反応ノート

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