Epichlorohydrin → 2-[(4-Benzoylphenoxy)methyl]oxirane

HRID 1742775

反応式

HRID 1742775 の反応式
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[CH2:16]([CH:18]1[O:20][CH2:19]1)Cl.[OH-].[Na+]>>[CH2:16]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1)[CH:18]1[O:20][CH2:19]1

参加物

4

反応物 3

HCID 7835EpichlorohydrinHCID 143474-HydroxybenzophenoneHCID 14798Sodium Hydroxide2 回

生成物 1

HCID 3528162-[(4-Benzoylphenoxy)methyl]oxirane収率 83%

反応条件

温度
100 °C

実験手順

1 g of 4-hydroxy benzophenone and 4.668 g of epichlorohydrin (0.025 mol) were dissolved, 20.5 mg of sodium hydroxide was added, and the reaction system was heated to 100° C. and then cooled to 95° C. Furthermore 201.4 mg of sodium hydroxide was added, and additional heating and agitation was carried out for 3 hours. The system was cooled to the room temperature, and salt was removed by filtering. The obtained filtrate was condensed under reduced pressure condition, and purified according to the silica gel chromatography to obtain 1.0 g of solid state 4-glycidyloxy benzophenone (Yield: 83%).

後処理

  1. temperaturecooled to 95° C
  2. temperatureadditional heating
  3. temperatureThe system was cooled to the room temperature, and salt
  4. customwas removed
  5. filtrationby filtering
  6. customcondensed under reduced pressure condition
  7. custompurified

出典と根拠

ORDレコード
ord-e85f38e65d7646519f71c006d78eed22
出典データセット
uspto-grants-1994_08
特許番号
US05342610

関連ノート

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