Potassium Hydroxide → (4-(2,3-Dihydroxypropoxy)phenyl)(phenyl)methanone

HRID 1742776

反応式

HRID 1742776 の反応式
C(O)[C@H]1[O:7][C@H](O[C@@H]([C@H](O)[C@@H](O)CO)[C@H](O)CO)[C@H](O)[C@@H](O)[C@@H]1O.[OH-].[K+].[CH2:26]([O:30][C:31]1[CH:44]=[CH:43][C:34]([C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:36])=[CH:33][CH:32]=1)[CH:27]1[O:29][CH2:28]1.Cl(O)(=O)=O>CS(C)=O.C(O)C.O>[C:35]([C:34]1[CH:43]=[CH:44][C:31]([O:30][CH2:26][CH:27]([CH2:28][OH:7])[OH:29])=[CH:32][CH:33]=1)(=[O:36])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

参加物

8

反応物 4

HCID 14797Potassium HydroxideHCID 19654Chloric acidHCID 3528162-[(4-Benzoylphenoxy)methyl]oxiraneHCID 493591Maltitol

生成物 1

HCID 58434142(4-(2,3-Dihydroxypropoxy)phenyl)(phenyl)methanone収率 64.9%

試薬・触媒・溶媒 3

HCID 679Dimethyl Sulfoxide溶媒2 回HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Then, 2.921 g of maltitol and 476.0 mg of potassium hydroxide were dissolved in 20 ml of dimethylsulfoxide, and the mixture was stirred under flow of nitrogen for 30 minutes. A solution obtained by dissolving 719 mg of the resultant 4-glycidyloxy benzophenone dissolved in 1 ml of dimethylsulfoxide was dripped to it. Furthermore, heating and agitation was continued for 1 hour under flow of nitrogen, and the reaction system was cooled to the room temperature and neutralize with chloric acid. The reaction system was fractionated according to the column chromatography using the hyperporous polymer (Hiporous resin supplied from Mitsubishi Kasei Kogyo Kabushiki Kaisha) at first as a developing solvent with purified water, and then a mixture of ethyl alcohol and purified water with the mixing ratio of 1:1, and effluent fraction in which the mixing ratio of ethyl alcohol and purified water was 1:1 was condensed to obtained 500 mg of 1-(4-benzoylphenyl) glycerol maltitolether (Yield: 30%).

後処理

  1. customA solution obtained
  2. temperatureFurthermore, heating
  3. waitagitation was continued for 1 hour under flow of nitrogen
  4. custompurified water with the mixing ratio of 1:1, and effluent fraction in which the mixing ratio of ethyl alcohol
  5. custompurified water
  6. customcondensed

出典と根拠

ORDレコード
ord-74cd75b302864997a8137d3a76122620
出典データセット
uspto-grants-1994_08
特許番号
US05342610

関連ノート

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