Hydrochloric Acid → Indenol

HRID 1742875

反応式

HRID 1742875 の反応式
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[BH4-].[Na+].[Cl-].[Ce+3].[Cl-].[Cl-].Cl>CO.O>[CH:1]1([OH:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 24636Cerium(III) chlorideHCID 4311764Sodium borohydrideHCID 118153841H-inden-1-one

生成物 1

HCID 316919Indenol収率 99%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

The indenone from Example 109 (0.5 g) is reduced with NaBH4 (0.05 g) and cerium chloride (0.5 g) in methanol (20 ml). The reaction is ended after 10 minutes and the reaction mixture is poured into water. The pH is taken to 5 by means of dilute HCl and the mixture is extracted with ethyl acetate. It is washed with water and the solvent is evaporated. Indenol (0.49 g; m.p. 134° C.) is obtained (yield: 99%; compound no. 110).

後処理

  1. extractionthe mixture is extracted with ethyl acetate
  2. washIt is washed with water
  3. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-cd9cf0ff7a204f888cf069744c378c51
出典データセット
uspto-grants-1994_08
特許番号
US05342835

関連ノート

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