Hydrochloric Acid → 3-(4,5-Dimethyl-1,2,3-triazol-1-yl)pyrrolidine hydrochloride
反応式
C([N:8]1[CH2:12][CH2:11][CH:10]([N:13]2[C:17]([CH3:18])=[C:16]([CH3:19])[N:15]=[N:14]2)[CH2:9]1)C1C=CC=CC=1.[ClH:20]>CO.[Pd]>[ClH:20].[CH3:19][C:16]1[N:15]=[N:14][N:13]([CH:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[C:17]=1[CH3:18]参加物
5
実験手順
10% Pd/C (0.5 g) was added to a solution of 0.86 g of N-benzyl-3-(4 , 5-dimethyl-1,2,3-triazol-1-yl) pyrrolidine in 50 ml of methanol, and 2 ml of 1N hydrochloric acid. The suspension was then hydrogenated at 50 psi pressure overnight. The Pd/C was removed by filtration through celite and the supernatant was evaporated to dryness and crystallized from methanol-ether to yield 0.5 g of the desired product. 1H NMR (D2O) δ: 5.75-5.6 (m, 1H), 4.14-3.9 (m, 2H), 3.8-3.6 (m, 2H), 2.86-2.4 (m, 8H, two singlets at 2.49 and 2.4).
後処理
- customwas then hydrogenated at 50 psi pressure overnight
- customThe Pd/C was removed by filtration through celite
- customthe supernatant was evaporated to dryness
- customcrystallized from methanol-ether
出典と根拠
- ORDレコード
- ord-e3fd37c791a24705af154157d6dd0581
- 出典データセット
- uspto-grants-1994_08
- 特許番号
- US05342846
反応ノート
読み込み中…