HCID 22238083、化合物 → HCID 22238093、化合物

HRID 1743387ノート

反応式

HRID 1743387 の反応式
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[C:5]([CH3:17])[C:6]([CH3:16])=[C:7]([O:11]CC(C)=C)[CH:8]=2)[N:3]1[CH:18]=[O:19]>C(N(CC)C1C=CC=CC=1)C.C(OCC)C>[OH:11][C:7]1[C:8]([CH2:6][C:5]([CH3:17])=[CH2:4])=[C:9]2[C:4](=[C:5]([CH3:17])[C:6]=1[CH3:16])[N:3]([CH:18]=[O:19])[CH:2]([CH3:1])[CH2:10]2

参加物

4

反応物 1

HCID 22238083HCID 22238083、化合物

生成物 1

HCID 22238093HCID 22238093、化合物収率 137.5%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 7061N,N-Diethylaniline溶媒

実験手順

A solution of 2,3-dihydro-2,6,7-trimethyl-5-[(2-methyl-2-propenyl)oxy]-1H-indole-1-carbaldehyde (0.59 g, 2.3 mmol) in N,N-diethylaniline (3 mL) was stirred at 200° C. for 4.5 hours under the nitrogen atmosphere. The reaction mixture was dissolved in diethyl ether, washed with 1N hydrochloric acid, water and saturated brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-diisopropyl ether to obtain 0.41 g of the title compound.

後処理

  1. washwashed with 1N hydrochloric acid, water and saturated brine
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was recrystallized from ethyl acetate-diisopropyl ether

出典と根拠

ORDレコード
ord-77f338ef10fd4377b99ae318e88d33c2
出典データセット
uspto-grants-2006_03
特許番号
US07008940B1

反応ノート

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