2-Fluoroethyl bromide → 2-(2-Fluoroethyl)-2-(4-methoxybenzyl)malononitrile

HRID 1743581

反応式

HRID 1743581 の反応式
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][CH:8]([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1.[H-].[Na+].Br[CH2:18][CH2:19][F:20]>CN(C)C=O>[F:20][CH2:19][CH2:18][C:8]([CH2:7][C:6]1[CH:13]=[CH:14][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)([C:11]#[N:12])[C:9]#[N:10]

参加物

5

反応物 3

HCID 129822-Fluoroethyl bromideHCID 24758Sodium hydrideHCID 27641412-(4-Methoxybenzyl)malononitrile

生成物 1

HCID 222349672-(2-Fluoroethyl)-2-(4-methoxybenzyl)malononitrile収率 50.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Using 0.37 g of (4-methoxybenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.25 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.23 g of 2-(2-fluoroethyl)-2-(4-methoxybenzyl)malononitrile (the present compound (52)).

出典と根拠

ORDレコード
ord-005d0d1113074435aeaec4eced442c4a
出典データセット
uspto-grants-2006_03
特許番号
US07011838B2

関連ノート

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