Sodium hydride → 2-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile

HRID 1743616

反応式

HRID 1743616 の反応式
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][CH:8]([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1.[H-].[Na+].Br[CH2:18][CH2:19][C:20]([F:23])([F:22])[F:21]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][C:8]([CH2:18][CH2:19][C:20]([F:23])([F:22])[F:21])([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 27641412-(4-Methoxybenzyl)malononitrile

生成物 1

HCID 222350142-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile収率 27.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Using 0.39 g of 2-(4-methoxybenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.34 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.15 g of 2-(4-methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (89)).

出典と根拠

ORDレコード
ord-4f1d0aa6a168436cbc40ac0b2139b8df
出典データセット
uspto-grants-2006_03
特許番号
US07011838B2

関連ノート

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