反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:13][C:12](=[O:14])[CH2:11][CH2:10][C@H:9]2[C:15]([O:17]C)=[O:16])=[CH:4][CH:3]=1.[OH-].[Li+].Cl.[Cl-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]2[CH2:13][C:12](=[O:14])[CH2:11][CH2:10][C@H:9]2[C:15]([OH:17])=[O:16])=[CH:6][CH:7]=1参加物
5
実験手順
A stirred mixture of methyl trans-2-(4-chlorophenyl)-4-oxocyclohexanecarboxylate (1.05 g, 3.94 mmol) and 1 N lithium hydroxide (5.91 mL, 5.91 mmol) in tetrahydrofuran (5 mL) was heated at reflux for approximately 1 h. After cooling to room temperature, the reaction mixture was poured into 1 N hydrochloric acid/brine (1:1) and extracted three times with methylene chloride. The combined organic extracts were washed with brine, dried (MgSO4) and concentrated in vacuo. The crude title compound was used without further purification in the subsequent reaction.
後処理
- temperaturewas heated
- temperatureat reflux for approximately 1 h
- extractionextracted three times with methylene chloride
- washThe combined organic extracts were washed with brine
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
- customThe crude title compound was used without further purification in the subsequent reaction
出典と根拠
- ORDレコード
- ord-2a81883c8cc6425c9b1f364cc91d3167
- 出典データセット
- uspto-grants-2006_03
- 特許番号
- US07012084B2
関連ノート
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