Hydrochloric Acid → HCID 28354564、化合物

HRID 1744057ノート

反応式

HRID 1744057 の反応式
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[Li+].[OH-].Cl>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:15])[CH3:16])[C:9]([OH:11])=[O:10])=[CH:17][CH:18]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86594553HCID 86594553、化合物

生成物 1

HCID 28354564HCID 28354564、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To methyl (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoate (2.198 g, 7.0 mmol) in MeOH (30 mL) was added an aqueous solution of LiOH (2 M, 17.5 mL, 35 mmol) and the reaction was stirred overnight. The reaction was neutralized with aqueous 10% HCl (pH of 6–7) and the product crystallized out of solution and was filtered and dried in vacuo to afford (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoic acid.

後処理

  1. customthe product crystallized out of solution
  2. filtrationwas filtered
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-27630d94e7314f20af4009d83d8fa504
出典データセット
uspto-grants-2006_03
特許番号
US07012075B2

反応ノート

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