Sodium Hydroxide → 4-Trifluoromethylnicotinamide
反応式
[F:1][C:2]([F:13])([F:12])[C:3](=O)[CH:4]=[CH:5][NH:6][CH:7]=[CH:8][C:9]#[N:10].[OH-].[Na+].CCCCCC.CC(C)=[O:24]>CO>[F:1][C:2]([F:13])([F:12])[C:3]1[C:8]([C:9]([NH2:10])=[O:24])=[CH:7][N:6]=[CH:5][CH:4]=1参加物
5
実験手順
3-[(4,4,4-Trifluoro-3-oxo-1-butenyl)amino]-2-propenenitrile (a low-polar compound IIa; 1.90 g, 10 mmol) was dissolved in methanol (15 ml), and sodium hydoxide (600 mg, 15 mmol) was added. The mixture was heated under reflux for 6 hours. The reaction mixture was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (a eluting solvent: hexane/acetone=1/1) to obtain 1.25 g (yield 65.6%) of the title compound.
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 6 hours
- concentrationThe reaction mixture was concentrated under reduced pressure
- customThe resulting residue was purified by silica gel column chromatography (a eluting solvent
出典と根拠
- ORDレコード
- ord-5e7bfbb39f69492881b917df499628d9
- 出典データセット
- uspto-grants-2006_03
- 特許番号
- US07015236B2
反応ノート
読み込み中…