Water → 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-4-carboxylic acid
反応式
O.[F:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[C:12]([C:14]([O:16]CC)=[O:15])[C:11]([CH3:19])=[N:10]2)=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[F:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH:13]=[C:12]([C:14]([OH:16])=[O:15])[C:11]([CH3:19])=[N:10]2)=[CH:7][CH:8]=1参加物
5
実験手順
To a mixed solvent of ethanol (40 ml) and water (40 ml) were added ethyl 1-(4-fluorophenyl)-3-methylpyrazole-4-carboxylate (8.5 g) and sodium hydroxide (1.66 g), and the mixture was stirred at a refluxing temperature for 2 h. After the reaction, ethanol was evaporated and to the residue was added dilute hydrochloric acid. The obtained solid was recrystallized from aqueous methanol solution to give the title compound, melting point: 194–195° C.
後処理
- customwas evaporated and to the residue
- additionwas added dilute hydrochloric acid
- customThe obtained solid was recrystallized from aqueous methanol solution
出典と根拠
- ORDレコード
- ord-acb36e67ecfe48ac937268c9f2f5f074
- 出典データセット
- uspto-grants-2006_03
- 特許番号
- US07015218B1
反応ノート
読み込み中…