Isoamyl Nitrite → Ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

HRID 1744470ノート

反応式

HRID 1744470 の反応式
N[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[N:5]=[CH:4][C:3]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15].N(OCCC(C)C)=O>O1CCCC1>[F:13][C:10]1[CH:9]=[CH:8][C:7]([N:6]2[CH:2]=[C:3]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:4]=[N:5]2)=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 8053Isoamyl NitriteHCID 688689ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

生成物 1

HCID 14994516Ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate収率 75.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ethyl 5-amino-1-(4-fluorophenyl)pyrazole-4-carboxylate (15 g) was dissolved in tetrahydrofuran (150 ml) and isoamyl nitrite (21.2 g) was added. The mixture was stirred at a refluxing temperature for 2 h. After cooling, the precipitated crystals were recrystallized from a mixed solvent of ethyl acetate-n-hexane to give the title compound (10.6 g).

後処理

  1. temperatureAfter cooling
  2. customthe precipitated crystals were recrystallized from a mixed solvent of ethyl acetate-n-hexane

出典と根拠

ORDレコード
ord-8a4f22ce48f446dca7089e1234ba5bfe
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

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