Sodium Hydroxide → 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

HRID 1744471ノート

反応式

HRID 1744471 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]([O:15]CC)=[O:14])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[N:9]2)=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 14994516Ethyl 1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

生成物 1

HCID 31596171-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid収率 95.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Ethyl 1-(4-fluorophenyl)pyrazole-4-carboxylate (10.6 g) was dissolved in a mixed solvent of ethanol (80 ml) and water (80 ml), and sodium hydroxide (2.2 g) was added. The mixture was stirred at a refluxing temperature for 30 min. After evaporation of ethanol, dilute hydrochloric acid was added to the residue. The obtained solid was recrystallized from aqueous methanol solution to give the title compound (8.9 g), melting point: 244–247° C.

後処理

  1. additionwas added
  2. customAfter evaporation of ethanol, dilute hydrochloric acid
  3. additionwas added to the residue
  4. customThe obtained solid was recrystallized from aqueous methanol solution

出典と根拠

ORDレコード
ord-784da902b3d9492aa6c5c20db22b11e8
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

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