Sodium Hydroxide → 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid

HRID 1744481ノート

反応式

HRID 1744481 の反応式
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([C:13]([O:15]C)=[O:14])=[N:3]1.[OH-].[Na+]>C(O)C.O>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([C:13]([OH:15])=[O:14])=[N:3]1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 21766260Methyl 1-methyl-5-phenyl-1h-pyrazole-3-carboxylate

生成物 1

HCID 75376191-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid収率 65.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Methyl 1-methyl-5-phenylpyrazole-3-carboxylate (3.6 g) was dissolved in a mixed solvent of ethanol (20 ml) and water (20 ml) and sodium hydroxide (0.8 g) was added. The mixture was stirred at a refluxing temperature for 30 min. Ethanol was evaporated and to the residue was added dilute hydrochloric acid. The obtained solid was recrystallized from aqueous methanol solution to give the title compound (2.2 g), melting point: 149–150° C.

後処理

  1. additionwas added
  2. customEthanol was evaporated and to the residue
  3. additionwas added dilute hydrochloric acid
  4. customThe obtained solid was recrystallized from aqueous methanol solution

出典と根拠

ORDレコード
ord-738d63e9dd764f438106eba37cc859f0
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

反応ノート

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