Pyridine → 1-(4-Chlorophenyl)-N-(4-chloro-3-nitrophenyl)-5-methylpyrazole-4-carboxamide

HRID 1744545

反応式

HRID 1744545 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.N1C=CC=CC=1.[Cl:23][C:24]1[CH:30]=[CH:29][C:27]([NH2:28])=[CH:26][C:25]=1[N+:31]([O-:33])=[O:32]>O>[Cl:23][C:24]1[CH:30]=[CH:29][C:27]([NH:28][C:14]([C:11]2[CH:10]=[N:9][N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[C:12]=2[CH3:13])=[O:15])=[CH:26][C:25]=1[N+:31]([O-:33])=[O:32]

参加物

5

反応物 3

HCID 1049PyridineHCID 124774-Chloro-3-nitroanilineHCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

生成物 1

HCID 222280911-(4-Chlorophenyl)-N-(4-chloro-3-nitrophenyl)-5-methylpyrazole-4-carboxamide収率 92.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-(4-Chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (1.7 g) was added to a pyridine solution of 4-chloro-3-nitroaniline (1 g) and the mixture was stirred at room temperature for 2 h. After the reaction, water was added and the precipitated solid was collected by filtration to give the title compound (2.1 g), melting point:221–225° C.

後処理

  1. additionwas added
  2. filtrationthe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-0694f807d2394b3ca2ffb8affed3564d
出典データセット
uspto-grants-2006_03
特許番号
US07015218B1

関連ノート

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