4-Chloro-3-Fluorobenzaldehyde → 1-(4-Chloro-3-fluorophenyl)ethan-1-ol

HRID 1744876ノート

反応式

HRID 1744876 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[F:10].[CH3:11]COCC.C[Mg+].[Br-]>C1COCC1>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]([OH:7])[CH3:11])=[CH:4][C:3]=1[F:10]

参加物

4

反応物 2

HCID 27249854-Chloro-3-FluorobenzaldehydeHCID 178467672HCID 178467672、化合物

生成物 1

HCID 219347441-(4-Chloro-3-fluorophenyl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-50 °C

実験手順

To a solution of 4-chloro-3-fluorobenzaldehyde (1 eq) in THF (0.3 M) at −78° C. was added 3M/Et2O MeMgBr (1.5 eq). The reaction mixture was stirred at −50° C. for 3 hrs, quenched with aqueous saturated NH4Cl and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated to give 1-(4-chloro-3-fluorophenyl)ethanol, which was used as such for the next step.

後処理

  1. customquenched with aqueous saturated NH4Cl
  2. extractionextracted with EtOAc
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-fe10e2668635412bb68af3e8a73e6205
出典データセット
uspto-grants-2006_03
特許番号
US07019022B2

反応ノート

読み込み中…