Benzo(d)thiazol-2-amine → ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylate

HRID 1744916ノート

反応式

HRID 1744916 の反応式
Br[CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1>CN(C=O)C>[N:10]1[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:2][N:15]2[C:14]3[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=3[S:12][C:11]=12

参加物

4

反応物 2

HCID 8706Benzo(d)thiazol-2-amineHCID 66144Ethyl bromopyruvate

生成物 1

HCID 1480574ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Ethyl bromopyruvate (9.8 g, 50 mmol) was added dropwise to a stirred solution of 2-aminobenzothiazole (7.5 g, 50 mmol) in DMF (100 ml) at room temperature. After the addition, the reaction mixture was heated to reflux for 6 h. The reaction mixture was cooled to room temperature and quenched with ice cold water. The aqueous layer was neutralized with NH4OH and the separated solid was fitered. It was washed well with water and dried. The crude product obtained was taken to next step without purification.

後処理

  1. additionAfter the addition
  2. temperaturethe reaction mixture was heated
  3. temperatureto reflux for 6 h
  4. customquenched with ice cold water
  5. washIt was washed well with water
  6. customdried

出典と根拠

ORDレコード
ord-63045a7327d34c5ca9b00b633ef3bf54
出典データセット
uspto-grants-2006_03
特許番号
US07018997B2

反応ノート

読み込み中…