Hydrochloric Acid → 5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-A]pyridin-2-amine

HRID 1744930ノート

反応式

HRID 1744930 の反応式
Cl.[N:2]1[C:3]([NH2:11])=[N:4][N:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12>C(O)C.[Pd]>[N:2]1[C:3]([NH2:11])=[N:4][N:5]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=12

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 584054[1,2,4]Triazolo[1,5-a]pyridin-2-amine

生成物 1

HCID 150625325,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-A]pyridin-2-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

The 12.7% solution of HCl in ethanol (5.35 mL) and 10% Pd—C (50% wet) (2.5 g) were added to the mixture of [1,2,4]triazolo[1,5-a]pyridin-2-ylamine (2.5 g) in ethanol (72 mL). The reaction mixture was hydrogenated at 400 KPa of H2 for 3 days at room temperature. The mixture was filtered and concentrated under reduced pressure. The residue was treated with saturated potassium carbonate solution and extracted with chloroform. The organic layer was dried (Na2SO4) and concentrated under reduced pressure. The title compound was obtained as a pale yellow solid (2.31 g, 90%). 1H-NMR (400 MHz, CDCl3) δ 1.88–1.94 (m, 2H), 1.98–2.05 (m, 2H), 2.77 (t, 2H, J=6.2 Hz), 3.95 (t, 2H, J=6.2 Hz), 4.09 (brs, 2H).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. additionThe residue was treated with saturated potassium carbonate solution
  4. extractionextracted with chloroform
  5. dry with materialThe organic layer was dried (Na2SO4)
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-956aa3e6e51546f5b7e295ef250d723d
出典データセット
uspto-grants-2006_03
特許番号
US07018997B2

反応ノート

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