Sodium Azide → HCID 22225783、化合物

HRID 1745391ノート

反応式

HRID 1745391 の反応式
Br[CH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]#[N:9])[N:7]=1.[N-:10]=[N+:11]=[N-:12].[Na+]>CN(C=O)C.O>[N:10]([CH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]#[N:9])[N:7]=1)=[N+:11]=[N-:12]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 220327292-(Bromomethyl)-1,3-thiazole-4-carbonitrile

生成物 1

HCID 22225783HCID 22225783、化合物収率 93.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

2-Bromomethyl-thiazole-4-carbonitrile (1.6 g, 7.8 mmol) was dissolved in 20 mL DMF and sodium azide (0.768 g, 11.8 mmol) was added. The reaction was allowed to stir for 16 h at room temperature and then diluted with water (50 mL). The aqueous layer was extracted with ethyl acetate (3×) and the combined organic layers were washed again with 75 ml of brine, dried with anhydrous sodium sulfate and concentrated in vacuo to yield 1.20 g (92%) of the title compound as a gummy material which was used in next step with out further purification.

後処理

  1. extractionThe aqueous layer was extracted with ethyl acetate (3×)
  2. washthe combined organic layers were washed again with 75 ml of brine
  3. dry with materialdried with anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-71ac20bd6f9a48cbb0dceee81c0556cf
出典データセット
uspto-grants-2006_03
特許番号
US07019019B2

反応ノート

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