4-((3,5-Dimethylisoxazol-4-yl)methoxy)benzene-1-sulfonyl chloride → 4-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(4-ethylphenyl)-N-isobutylbenzenesulfonamide

HRID 1746421ノート

反応式

HRID 1746421 の反応式
[CH2:1]([C:3]1[CH:13]=[CH:12][C:6]([NH:7][CH2:8][CH:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=1)[CH3:2].[CH3:14][C:15]1[C:19]([CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=2)=[C:18]([CH3:32])[O:17][N:16]=1>N1C=CC=CC=1>[CH3:14][C:15]1[C:19]([CH2:20][O:21][C:22]2[CH:23]=[CH:24][C:25]([S:28]([N:7]([C:6]3[CH:12]=[CH:13][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=3)[CH2:8][CH:9]([CH3:10])[CH3:11])(=[O:30])=[O:29])=[CH:26][CH:27]=2)=[C:18]([CH3:32])[O:17][N:16]=1

参加物

4

反応物 2

HCID 164907024-((3,5-Dimethylisoxazol-4-yl)methoxy)benzene-1-sulfonyl chlorideHCID 284793854-ethyl-N-(2-methylpropyl)aniline

生成物 1

HCID 715434874-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(4-ethylphenyl)-N-isobutylbenzenesulfonamide収率 83%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To 4-ethyl-N-isobutylaniline (50 mg, 0.282 mmol) in pyridine (1 mL) was added 4-{[(3,5-dimethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (94 mg, 0.310 mmol) and the reaction stood at room temperature, in air, for 16 hours. The crude was then purified by MDAP (Method F), to provide 103.6 mg of desired product. LCMS (M+1) 443, RT 1.39 mins.

後処理

  1. customThe crude was then purified by MDAP (Method F)

出典と根拠

ORDレコード
ord-4112b51de7e14304960be5b5953077f5
出典データセット
uspto-grants-2015_10
特許番号
US09150508B2

反応ノート

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