N-Carbobenzoxy-L-tryptophanamide → L-Tryptophanamide

HRID 1746588ノート

反応式

HRID 1746588 の反応式
C(OC([NH:11][C@H:12]([C:23]([NH2:25])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1)=O)C1C=CC=CC=1.[H][H]>[Pd].CO>[NH2:11][C@H:12]([C:23]([NH2:25])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1

参加物

5

反応物 2

HCID 853880N-Carbobenzoxy-L-tryptophanamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 439356L-Tryptophanamide収率 96.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To methanol (300 mL) solution of the compound obtained in Example 125 (3.6 g) was added 5% palladium/carbon (0.36 g) in an argon atmosphere, and the mixture was stirred for 16 hours at room temperature in a hydrogen atmosphere. The catalyst was filtered off, and the solvent was distilled off under a reduced pressure, to give the captioned compound (2.1 g, 95%) as an oily product.

後処理

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off under a reduced pressure

出典と根拠

ORDレコード
ord-21aa14b37a5e46d8b9bb1e0555ac93a1
出典データセット
uspto-grants-2015_10
特許番号
US09150510B2

反応ノート

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