Oxygen → Qing Hau Sau

HRID 1746629

反応式

HRID 1746629 の反応式
[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C@H:13]([C:15]([OH:17])=[O:16])[CH3:14])[CH2:4][CH2:3]1.C1C=CC(C2C3NC(C(C4C=CC=CC=4)=C4C=CC(=C(C5C=CC=CC=5)C5C=CC(=C(C6C=CC=CC=6)C6C=CC=2N=6)N=5)N4)=CC=3)=CC=1.[O:66]=[O:67].FC(F)(F)C(O)=[O:71]>C1(C)C=CC=CC=1>[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C@:10]3([CH3:12])[O:66][O:67][C@:6]42[C@H:5]([C@@H:13]([CH3:14])[C:15]([O:17][C@@H:11]4[O:71]3)=[O:16])[CH2:4][CH2:3]1

参加物

6

反応物 4

HCID 977OxygenHCID 6422Trifluoroacetic acid2 回HCID 701865,10,15,20-Tetraphenyl-21,22-dihydroporphyrinHCID 11020893Dihydroartemisinic acid

生成物 1

HCID 9838675Qing Hau Sau収率 62%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

The feed was a solution of dihydroartemisinic acid at a concentration of 0.5 mol/L and the photosensitizer tetraphenylporphyrin at a concentration of 1 mmol/L in toluene (2.95 g dihydroartemisinic acid and 15 mg tetraphenylporphyrin, total volume 25 mL, volumetric flask). The feed was introduced at a flow rate of 1.25 mL/min and the oxygen flow adjusted to 5 mL/min. The solution of trifluoroacetic acid injected into the output stream of the photochemical reactor contains 1.93 mL trifluoroacetic acid filled up to 20 ml with toluene (1.25 M, volumetric flask). The output stream showed a conversion of 89% yielding 62% of the desired artemisinin with a selectivity of 70% (NMR of crude).

後処理

  1. additionThe feed was introduced at a flow rate of 1.25 mL/min

出典と根拠

ORDレコード
ord-056272f6b877429483a9953680863e93
出典データセット
uspto-grants-2015_10
特許番号
US09150535B2

関連ノート

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