Hydrazine hydrate (1:1) → tert-butyl 1-(2-aminoethyl)-1H-pyrrole-3-carboxylate

HRID 1747046ノート

反応式

HRID 1747046 の反応式
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][N:14]1[CH:18]=[CH:17][C:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[CH:15]1.O.NN>C(O)C>[NH2:3][CH2:12][CH2:13][N:14]1[CH:18]=[CH:17][C:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[CH:15]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 59478522tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1H-pyrrole-3-carboxylate

生成物 1

HCID 59479135tert-butyl 1-(2-aminoethyl)-1H-pyrrole-3-carboxylate収率 105.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

A mixture of 660 mg of tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1H-pyrrole-3-carboxylate, 194 mg of hydrazine monohydrate, and 19 ml of ethanol was stirred at 70° C. for 12 hours. The reaction solution was left to be cooled and the insoluble material was then separated by filtration. The filtrate was concentrated under reduced pressure to obtain 430 mg of tert-butyl 1-(2-aminoethyl)-1H-pyrrole-3-carboxylate as a yellow oily substance.

後処理

  1. waitThe reaction solution was left
  2. temperatureto be cooled
  3. customthe insoluble material was then separated by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-03558eb0cf13447a9f499a9c416a9a56
出典データセット
uspto-grants-2015_10
特許番号
US09150541B2

反応ノート

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