(S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-hexanoic acid ethyl ester → Ethyl (3S)-3-aminohexanoate
反応式
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C@@H:6]([N:10](CC1C=CC=CC=1)[C@H](C1C=CC=CC=1)C)[CH2:7][CH2:8][CH3:9])[CH3:2]>CCO.[OH-].[OH-].[Pd+2]>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C@@H:6]([NH2:10])[CH2:7][CH2:8][CH3:9])[CH3:2]参加物
4
実験手順
To a solution of (S)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-hexanoic acid ethyl ester (20.8 g, 59 mmol) in EtOH (50 mL) was added Pd(OH)2 (20% in carbon) (2 g). The mixture was stirred under hydrogen atmosphere with 40 psi for 16 hours. The mixture was filtered and the filtrate was concentrated. The residue (8.2 g, 87%) was used in the next step of the synthesis without further purification.
後処理
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated
- customThe residue (8.2 g, 87%) was used in the next step of the synthesis without further purification
出典と根拠
- ORDレコード
- ord-c0d8387fd78b42c98676a2b928256738
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150556B2
反応ノート
読み込み中…