(S)-3-(2-Nitro-phenylamino)-hexanoic acid ethyl ester → (S)-3-(2-Amino-phenylamino)-hexanoic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:20])[CH2:5][C@@H:6]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-])=O)[CH2:7][CH2:8][CH3:9])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:20])[CH2:5][C@@H:6]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[NH2:17])[CH2:7][CH2:8][CH3:9])[CH3:2]参加物
4
実験手順
To a solution of (S)-3-(2-Nitro-phenylamino)-hexanoic acid ethyl ester (795 mg, 2.8 mmol) in EtOH (20 mL) was added Pd/C (10% wt on carbon) (300 mg). The solution was stirred at room temperature for 3 hours. The solution was filtered and the filtrate was concentrated. The residue (683 mg, 96%) was used in the next step of the synthesis without further purification.
後処理
- filtrationThe solution was filtered
- concentrationthe filtrate was concentrated
- customThe residue (683 mg, 96%) was used in the next step of the synthesis without further purification
出典と根拠
- ORDレコード
- ord-82ac7aa32dfe417f86dac980a5ae2426
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150556B2
反応ノート
読み込み中…