(S)-2-(2-Nitro-phenylamino)-propionic acid tert-butyl ester → (S)-2-(2-Amino-phenylamino)-propionic acid tert-butyl ester

HRID 1747386ノート

反応式

HRID 1747386 の反応式
[C:1]([O:5][C:6](=[O:19])[C@@H:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-])=O)[CH3:8])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:19])[C@@H:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16])[CH3:8])([CH3:2])([CH3:3])[CH3:4]

参加物

4

反応物 1

HCID 59497415(S)-2-(2-Nitro-phenylamino)-propionic acid tert-butyl ester

生成物 1

HCID 59497437(S)-2-(2-Amino-phenylamino)-propionic acid tert-butyl ester収率 105.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (S)-2-(2-Nitro-phenylamino)-propionic acid tert-butyl ester (1.6 g, 6.0 mmol) in MeOH (20 mL) was added a slurry of 10% Pd/C (dry) (300 mg). The reaction mixture was degasses using house vacuum aspirator and then saturated with H2 gas in balloon. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was then filtered through a celite and the filtrate was concentrated to afford 1.5 g (100%) of the desired product as a dark brown oily residue. This product was used for the next reaction without purification.

後処理

  1. filtrationThe reaction mixture was then filtered through a celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-d68b5dac7c4546a0829b4defaeedd18c
出典データセット
uspto-grants-2015_10
特許番号
US09150556B2

反応ノート

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