[1-(2-Nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester → [1-(2-Amino-phenylamino)-cyclohexyl]-acetic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1参加物
4
実験手順
A mixture of [1-(2-nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester (230 mg, 0.79 mmol), 10% Pd/C (80 mg) in EtOH (20 mL) under H2 atmosphere at room temperature was stirred for 16 h. The reaction mixture was filtered and the organic layer was concentrated to give the desired [1-(2-amino-phenylamino)-cyclohexyl]-acetic acid methyl ester (205 mg, 99%).