2-Methyl-2-(2-nitro-phenylamino)-propionic acid tert-butyl ester → HCID 59497586、化合物
反応式
[C:1]([O:5][C:6](=[O:20])[C:7]([CH3:19])([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-])=O)[CH3:8])([CH3:4])([CH3:3])[CH3:2]>CCO.[Pd]>[C:1]([O:5][C:6](=[O:20])[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16])([CH3:19])[CH3:8])([CH3:2])([CH3:3])[CH3:4]参加物
4
実験手順
A mixture of 2-methyl-2-(2-nitro-phenylamino)-propionic acid tert-butyl ester (638 mg, 2.3 mmol), 10% Pd/C (110 mg) in EtOH (25 mL) under H2 atmosphere at room temperature was stirred for 30 min. The reaction mixture was filtered and the organic layer was concentrated to give the desired 2-(2-amino-phenylamino)-2-methyl-propionic acid tert-butyl ester (570 mg, 100%).
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe organic layer was concentrated
出典と根拠
- ORDレコード
- ord-09e0868281784916bad716eda4ebc45d
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150556B2
反応ノート
読み込み中…