Methyl 2-((2-nitrophenyl)amino)benzoate → Methyl 2-(2-aminoanilino)benzoate

HRID 1747427ノート

反応式

HRID 1747427 の反応式
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-])=O>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[NH2:17]

参加物

4

反応物 1

HCID 292094Methyl 2-((2-nitrophenyl)amino)benzoate

生成物 1

HCID 13114778Methyl 2-(2-aminoanilino)benzoate収率 93%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

2-(2-Nitro-phenylamino)-benzoic acid methyl ester (200 mg, 0.74 mmol) is suspended in EtOAc (5.0 mL)) and 10% Pd/C wet (78 mg, 0.073 mmol) is added into it. A H2 balloon is attached to the reaction flask and the reaction mixture is stirred under H2 for 20 hrs. Then the Pd/C is filtered and the filtrated is concentrated to give 165 mg (93%) of 2-(2-Amino-phenylamino)-benzoic acid methyl ester.

後処理

  1. additionis added into it
  2. filtrationThen the Pd/C is filtered
  3. concentrationthe filtrated is concentrated

出典と根拠

ORDレコード
ord-20e7940e4e344a9ba387c3c222c36f67
出典データセット
uspto-grants-2015_10
特許番号
US09150556B2

反応ノート

読み込み中…