Dimethylformamide → 3-Bromo-5-phenylpyrazin-2(1H)-one

HRID 1747777ノート

反応式

HRID 1747777 の反応式
[C:1]1([C:7]2[N:8]=[CH:9][C:10](=[O:13])[NH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:14]N1C(=O)CCC1=O.CN(C=O)C>O>[Br:14][C:9]1[C:10](=[O:13])[NH:11][CH:12]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 67184N-bromobutanimideHCID 5990375-phenyl-1H-pyrazin-2-one

生成物 1

HCID 124535473-Bromo-5-phenylpyrazin-2(1H)-one収率 14.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5-phenylpyrazin-2(1H)-one (0.86 g), N-bromosuccinimide (0.89 g) and DMF (16 mL) was stirred at room temperature for 2 hr. The reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was washed with hexane to give the title compound (0.18 g).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. washThe residue was washed with hexane

出典と根拠

ORDレコード
ord-e3f95176644442dd8ee68b8a0625502d
出典データセット
uspto-grants-2015_10
特許番号
US09150588B2

反応ノート

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