Hydrochloric Acid → Cyclohexanone, 2-[(phenylmethoxy)methyl]-

HRID 1748171ノート

反応式

HRID 1748171 の反応式
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:19][CH2:18][CH2:17][CH2:16][C:11]21OCC[O:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH2:1]([O:8][CH2:9][CH:10]1[CH2:19][CH2:18][CH2:17][CH2:16][C:11]1=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 686237586-((Benzyloxy)methyl)-1,4-dioxaspiro[4.5]decane

生成物 1

HCID 10489011Cyclohexanone, 2-[(phenylmethoxy)methyl]-

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 6-((Benzyloxy)methyl)-1,4-dioxaspiro[4.5]decane (2.4 g 9.1 mmol) in acetone (40 mL) was treated with 1.5N HCl (18 mL) and stirred at rt for 5 hours. The reaction mixture was neutralized with aqueous sodium carbonate and the volatile removed in vacuo. The residue was extracted with Et2O (3×50 mL) and the combined organic layer were washed with water (30 mL), brine (30 mL) and dried over sodium sulfate and concentrated to yield the desired product as pale yellow oil that was used in the next step without further purification. MS m/z 219.1 (M+1).

後処理

  1. customthe volatile removed in vacuo
  2. extractionThe residue was extracted with Et2O (3×50 mL)
  3. washthe combined organic layer were washed with water (30 mL), brine (30 mL)
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-5c7a327edd30448b824639d9178071f1
出典データセット
uspto-grants-2015_10
特許番号
US09150568B2

反応ノート

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