Hydrochloric Acid → 5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylic acid

HRID 1748271ノート

反応式

HRID 1748271 の反応式
[OH-].[Na+].[CH3:3][CH:4]1[N:10]2[C:11]3[CH:12]=[C:13]([C:18]([O:20]CC)=[O:19])[CH:14]=[CH:15][C:16]=3[CH:17]=[C:9]2[C:8](=[O:23])[NH:7][CH2:6][CH2:5]1.Cl>C(O)C>[CH3:3][CH:4]1[N:10]2[C:11]3[CH:12]=[C:13]([C:18]([OH:20])=[O:19])[CH:14]=[CH:15][C:16]=3[CH:17]=[C:9]2[C:8](=[O:23])[NH:7][CH2:6][CH2:5]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67235486ethyl 5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylate

生成物 1

HCID 672353965-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylic acid収率 93.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

1 NaOH solution (60 mL, 60 mmol) is added to a solution of ethyl 5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylate (7.0 g, 24 mmol) in ethanol (75 mL). The reaction mixture is refluxed for 1.5 h. Then the reaction mixture is acidified with 1M HCl and ethanol is removed under vacuum. The resulting solid is filtered, washed with water and dried to afford the title compound (5.8 g, 92%) as a solid.

後処理

  1. temperatureThe reaction mixture is refluxed for 1.5 h
  2. customis removed under vacuum
  3. filtrationThe resulting solid is filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-b4099f8b93fd4d88b2fd38f6f876c00e
出典データセット
uspto-grants-2015_10
特許番号
US09150577B2

反応ノート

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