Sodium Hydroxide → HCID 67237069、化合物
反応式
[CH3:1][C@@H:2]1[N:8]2[C:9]3[CH:10]=[C:11]([C:16]([O:18]CC)=[O:17])[CH:12]=[CH:13][C:14]=3[CH:15]=[C:7]2[C:6](=[O:21])[NH:5][CH2:4][CH2:3]1.[OH-].[Na+]>C(O)C>[CH3:1][C@@H:2]1[N:8]2[C:9]3[CH:10]=[C:11]([C:16]([OH:18])=[O:17])[CH:12]=[CH:13][C:14]=3[CH:15]=[C:7]2[C:6](=[O:21])[NH:5][CH2:4][CH2:3]1参加物
4
実験手順
To a solution of ethyl (5S)-5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylate (1.9 g, 6.7 mmol) in ethanol (75 mL) is added 1N NaOH solution (16 mL, 16 mmol). The reaction mixture is refluxed for 1.5 h and cooled to room temperature. The ethanol is removed under vacuum and the residue is diluted with water. The mixture is acidified with aqueous 1N HCl solution the resulting solid is collected by filtration, rinsed with water and dried to afford the title compound (1.7 g, 99%).