Ammonium Chloride → HCID 10797271、化合物

HRID 1748321ノート

反応式

HRID 1748321 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH3:10])[C:5]([N+:11]([O-])=O)=[CH:4][CH:3]=1.[Cl-].[NH4+]>C(O)C.O.CCOC(C)=O.[Fe]>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH3:10])[C:5]([NH2:11])=[CH:4][CH:3]=1

参加物

7

反応物 2

HCID 25517Ammonium ChlorideHCID 107267696-Chloro-N-ethyl-3-nitropyridin-2-amine

生成物 1

HCID 10797271HCID 10797271、化合物収率 100%

試薬・触媒・溶媒 4

HCID 23925Iron触媒HCID 702Ethanol溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
140 °C

実験手順

To a solution of 6-chloro-N-ethyl-3-nitropyridin-2-amine (1.82 g, 9.04 mmol) in ethanol (20 mL) is added iron powder (2.52 g, 45.2 mmol) followed by a solution of ammonium chloride (2.42 g, 45.2 mmol) in water (8 mL). The mixture is heated in a microwave reactor at 140° C. for 30 min. The mixture is diluted with EtOAc, filtered and evaporated to afford the title compound as a brown oil (1.55 g, 100%) which was used in the next step without purification.

後処理

  1. filtrationfiltered
  2. customevaporated

出典と根拠

ORDレコード
ord-89972770bdcd46948f25ecb05a653859
出典データセット
uspto-grants-2015_10
特許番号
US09150577B2

反応ノート

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