Ethoxalyl chloride → Ethyl[(3,3-dimethyl-2-oxobutyl)amino](oxo)acetate
反応式
Cl.[NH2:2][CH2:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6].C(N(CC)C(C)C)(C)C.Cl[C:20](=[O:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22]>C(Cl)Cl>[CH2:24]([O:23][C:21](=[O:22])[C:20]([NH:2][CH2:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6])=[O:26])[CH3:25]参加物
5
実験手順
To a mixture of 1-amino-3,3-dimethylbutan-2-one hydrochloride salt (35 g, 231 mmol) in CH2Cl2 (500 mL) at 0° C. are added N,N-diisopropylethylamine (74 g, 577 mmol) and ethyl chloro(oxo)acetate (31.5 g, 231 mmol) slowly over a period of 15 min. The reaction mixture is stirred at room temperature for 2 h and is filtered through Celite. The filtrate is concentrated to afford the title compound (40 g, 81%).
後処理
- filtrationis filtered through Celite
- concentrationThe filtrate is concentrated
出典と根拠
- ORDレコード
- ord-12fcdcfefc2e4f7b886a1a5705332ca9
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150577B2
反応ノート
読み込み中…