Benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate → 5-Tert-butyl-1,3-oxazol-2-amine

HRID 1748331ノート

反応式

HRID 1748331 の反応式
[C:1]([C:5]1[O:9][C:8]([NH:10]C(=O)OCC2C=CC=CC=2)=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([C:5]1[O:9][C:8]([NH2:10])=[N:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 14054539Benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate

生成物 1

HCID 146232945-Tert-butyl-1,3-oxazol-2-amine収率 68%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of benzyl (5-tert-butyl-1,3-oxazol-2-yl)carbamate (5.0 g, 18.2 mmol) in methanol (100 mL) is added 10% palladium on carbon (500 mg, 0.5 mmol). The reaction is stirred at room temperature for 3 h under hydrogen atmosphere. The reaction mixture is filtered through Celite and the filtrate is concentrated. The residue is purified by flash column chromatography to afford the title compound (1.7 g, 68%) as a light brown solid.

後処理

  1. filtrationThe reaction mixture is filtered through Celite
  2. concentrationthe filtrate is concentrated
  3. customThe residue is purified by flash column chromatography

出典と根拠

ORDレコード
ord-c8351d8a8e604ec1911bc060e66eade0
出典データセット
uspto-grants-2015_10
特許番号
US09150577B2

反応ノート

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