Hydrochloric Acid → 1-(4-Ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

HRID 1748456ノート

反応式

HRID 1748456 の反応式
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)[C:12]=1[CH3:13])=[O:7])C.Cl>C(O)C>[CH2:21]([O:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]2)=[CH:19][CH:18]=1)[CH3:22]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 866924251-(4-ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

生成物 1

HCID 820860711-(4-Ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid収率 96%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

1N Aqueous solution of sodium hydroxide (4.8 ml) was added to a solution of 1-(4-ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.3 g) in ethanol (24 ml) at room temperature and stirred at 70° C. for three hours. After completion of the reaction, the reaction solution was cooled to room temperature, 1N hydrochloric acid aqueous solution was added and the precipitated solid was collected by filtration to give the titled compound (1.12 g) as a white solid.

後処理

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled to room temperature
  3. filtrationthe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-bcec41ce361f4bf18ebf05da1ae0e7dc
出典データセット
uspto-grants-2015_10
特許番号
US09150555B2

反応ノート

読み込み中…