Water → 1-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid

HRID 1748485ノート

反応式

HRID 1748485 の反応式
FC(F)(F)C(O)=O.C([O:12][C:13]([C:15]1[CH:19]=[CH:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][N:21]=2)[CH:16]=1)=[O:14])(C)(C)C.O>ClCCl>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([N:17]2[CH:18]=[CH:19][C:15]([C:13]([OH:14])=[O:12])=[CH:16]2)=[N:21][CH:22]=1

参加物

5

反応物 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 866924471-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid tert-butyl ester

生成物 1

HCID 866924481-(5-Chloropyridin-2-yl)pyrrole-3-carboxylic acid収率 97%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (3 ml) was added to a solution of 1-(5-chloropyridin-2-yl)pyrrole-3-carboxylic acid tert-butyl ester (1.0 g) in dichloromethane (10 ml) and stirred at room temperature for four hours. Water was added to the reaction solution and the precipitated solid was washed with water to give the titled compound (775 mg) as a gray solid.

後処理

  1. washthe precipitated solid was washed with water

出典と根拠

ORDレコード
ord-7bd8f627acfb4b40a3a5b55cea1781c8
出典データセット
uspto-grants-2015_10
特許番号
US09150555B2

反応ノート

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