Water → 3-Fluoro-2-hydrazinyl-5-(trifluoromethyl)pyridine
反応式
O.[NH2:2][NH2:3].F[C:5]1[C:10]([F:11])=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:7][N:6]=1.O>C(O)C>[F:11][C:10]1[C:5]([NH:2][NH2:3])=[N:6][CH:7]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=1参加物
5
実験手順
To a solution of hydrazine hydrate (100%) (3.45 ml) in ethanol (150 ml) was added dropwise a solution of 2,3-difluoro-5-(trifluoromethyl)pyridine (4.45 g) in ethanol (50 ml) at room temperature, stirred at the same temperature for 2 hours, and then additionally stirred at 80° C. for 2 hours. Then, the mixture was allowed to cool, water was added thereto, and the organic solvent was evaporated in vacuo. The precipitated solid was collected by filtration, and washed with water to give 3-fluoro-5-(trifluoromethyl)pyridin-2-ylhydrazine as a white solid.
後処理
- stirringadditionally stirred at 80° C. for 2 hours
- temperatureto cool
- customthe organic solvent was evaporated in vacuo
- filtrationThe precipitated solid was collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-dbc2f79b9a6c4bc5931dbe069eb53496
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150555B2
反応ノート
読み込み中…