Trifluoroacetic acid → HCID 86692505、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1([C:16]2[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][N:17]=2)[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].FC(F)(F)C(O)=O>>[CH2:1]([O:3][C:4]([C:6]1([C:16]2[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][N:17]=2)[CH2:15][CH2:14][C:9](=[O:10])[CH2:8][CH2:7]1)=[O:5])[CH3:2]参加物
3
実験手順
To 8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester (1.0 g) described in Reference Example 81 (2) was added trifluoroacetic acid (1.1 ml) at room temperature, and stirred at the same temperature for 2 hours. After completion of the reaction, the solvent and trifluoroacetic acid were evaporated. The obtained residue was purified with silica gel column chromatography (n-hexane/ethyl acetate) to give 1-(5-bromopyridin-2-yl)-4-oxocyclohexanecarboxylic acid ethyl ester (803 mg) as a colorless oil.
後処理
- customAfter completion of the reaction
- customthe solvent and trifluoroacetic acid were evaporated
- customThe obtained residue was purified with silica gel column chromatography (n-hexane/ethyl acetate)